Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTK2O1Q)

DTT Name	Nodal homolog (NODAL)
Synonyms	nodal growth differentiation factor; HTX5
Gene Name	NODAL
DTT Type	Literature-reported target	[1]
BioChemical Class	Growth factor
UniProt ID	NODAL_HUMAN
TTD ID	T87448
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MHAHCLPFLLHAWWALLQAGAATVATALLRTRGQPSSPSPLAYMLSLYRDPLPRADIIRS LQAEDVAVDGQNWTFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPD TEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPGALEKQMSRVAGEC WPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHL PDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLL KRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGCL
Function	Essential for mesoderm formation and axial patterning during embryonic development.
KEGG Pathway	Cytokine-cytokine receptor interaction (hsa04060 ) TGF-beta signaling pathway (hsa04350 ) Signaling pathways regulating pluripotency of stem cells (hsa04550 )
Reactome Pathway	Regulation of signaling by NODAL (R-HSA-1433617 ) Signaling by NODAL (R-HSA-1181150 )

References

1	Elevated expression of Nodal and YAP1 is associated with poor prognosis of gastric adenocarcinoma. J Cancer Res Clin Oncol. 2016 Aug;142(8):1765-73.