Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTK4JTZ)

• DTT Name: Guanine deaminase (GDA)
• Synonyms: p51-nedasin; KIAA1258; Guanine aminohydrolase; Guanase; GAH
• Gene Name: GDA
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Metallo-dependent hydrolase superfamily. ATZ/TRZ family
• UniProt ID: GUAD_HUMAN
• TTD ID: T92460
• EC Number: EC 3.5.4.3
• Sequence:
  MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
  KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
  EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
  KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH
  ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
  CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
  KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
  SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
• Function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
• KEGG Pathway:
  Purine metabolism (hsa00230)
  Metabolic pathways (hsa01100)
• Reactome Pathway: Purine catabolism (R-HSA-74259)
• BioCyc Pathway: MetaCyc:HS04276-MON

References

• [1] Studies on guanine deaminase and its inhibitors in rat tissue. Biochem J. 1967 Mar;102(3):691-704.