General Information of Drug Therapeutic Target (DTT) (ID: TTK5OG6)

DTT Name Proteolipid protein 2 (PLP2)
Synonyms PLP2; Intestinal membrane A4 protein; Differentiation-dependent protein A4
Gene Name PLP2
DTT Type
Literature-reported target
[1]
BioChemical Class
Plasmolipin family
UniProt ID
PLP2_HUMAN
TTD ID
T50072
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSASTPGYSSLSVIEMILA
AIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGNHSKIVAGVLGLI
ATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV
Function May play a role in cell differentiation in the intestinal epithelium.

References

1 MiR-422a weakened breast cancer stem cells properties by targeting PLP2. Cancer Biol Ther. 2018 May 4;19(5):436-444.