Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTK982E)

• DTT Name: Collagen (CO)
• Gene Name: NO-GeName
• DTT Type: Successful target; [1]
• Related Disease:
  Amoebiasis [ICD-11: 1A36]
  Skin sensation disturbance [ICD-11: ME65]
  Vitamin deficiency [ICD-11: 5B55-5B5F]
• UniProt ID: NOUNIPROTAC
• TTD ID: T68934

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Collagenase	DMFJ2OG	Dermal ulcers	1A36	Approved	[1], [2]
Vitamin C	DMXJ7O8	Vitamin C deficiency	5B56	Approved	[3]

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MRG-201	DM9M5WV	Keloid	EE60	Phase 2	[4]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clostridial collagenase	DMWTBG8	Discovery agent	N.A.	Investigative	[5]

References

• [1] Contact dermatitis with clostridiopeptidase A contained in Noruxol ointment. Contact Dermatitis. 2007 Jun;56(6):361-2.
• [2] Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. Cancer Epidemiol Biomarkers Prev. 2002 Jul;11(7):646-53.
• [3] Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram. Skin Res Technol. 2009 May;15(2):214-7.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Collagen as a clinical target: nonoperative treatment of Dupuytren's disease. J Hand Surg Am. 2002 Sep;27(5):788-98.