General Information of Drug Therapeutic Target (DTT) (ID: TTKGEBL)

DTT Name Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Synonyms eIF4E-binding protein 1; Phosphorylated heat- andacid-stable protein regulated by insulin 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; 4E-BP1
Gene Name EIF4EBP1
DTT Type
Literature-reported target
[1]
UniProt ID
4EBP1_HUMAN
TTD ID
T84941
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLM
ECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
Function
In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation.
KEGG Pathway
EGFR tyrosine kinase inhibitor resistance (hsa01521 )
ErbB signaling pathway (hsa04012 )
HIF-1 signaling pathway (hsa04066 )
mTOR signaling pathway (hsa04150 )
PI3K-Akt signaling pathway (hsa04151 )
AMPK signaling pathway (hsa04152 )
Longevity regulating pathway (hsa04211 )
Cellular senescence (hsa04218 )
Insulin signaling pathway (hsa04910 )
Human cytomegalovirus infection (hsa05163 )
Human papillomavirus infection (hsa05165 )
Herpes simplex virus 1 infection (hsa05168 )
Chemical carcinogenesis - receptor activation (hsa05207 )
Acute myeloid leukemia (hsa05221 )
Choline metabolism in cancer (hsa05231 )
Reactome Pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662 )
mTORC1-mediated signalling (R-HSA-166208 )

References

1 EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinoma. PLoS One. 2015 Feb 6;10(2):e0117493.