Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTKIGZF)

DTT Name	Guanine nucleotide exchange factor (GNEF)
Synonyms	eIF-2B GDP-GTP exchange factor; Translation initiation factor eIF-2B; EIF2B
Gene Name	EIF2B1
DTT Type	Clinical trial target	[1]
UniProt ID	EI2BA_HUMAN ; EI2BB_HUMAN
TTD ID	T84591
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL IKLYL
Function	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
KEGG Pathway	Herpes simplex virus 1 infection (hsa05168 )
Reactome Pathway	Recycling of eIF2 (R-HSA-72731 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Plinabulin	DMD7L48	Non-small-cell lung cancer	2C25.Y	Phase 3	[1]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)