General Information of Drug Therapeutic Target (DTT) (ID: TTKS60G)

DTT Name STXBP4 messenger RNA (STXBP4 mRNA)
Synonyms Syntaxin-binding protein 4 (mRNA); Syntaxin 4-interacting protein (mRNA); Synip (mRNA); STX4-interacting protein (mRNA)
Gene Name STXBP4
DTT Type
Literature-reported target
[1]
BioChemical Class
mRNA target
UniProt ID
STXB4_HUMAN
TTD ID
T82372
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYK
DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSC
TSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALR
QQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL
KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMAR
KTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLAL
ESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN
EEDCSRELPNQKS
Function
Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 119262 DMIS715 Discovery agent N.A. Investigative [1]
ISIS 119263 DMD3M9J Discovery agent N.A. Investigative [1]
ISIS 119264 DM0P3R5 Discovery agent N.A. Investigative [1]
ISIS 119281 DMFPM5S Discovery agent N.A. Investigative [1]
ISIS 119282 DMLND5S Discovery agent N.A. Investigative [1]
ISIS 119283 DMKJ57H Discovery agent N.A. Investigative [1]
ISIS 119284 DM7CTVE Discovery agent N.A. Investigative [1]
ISIS 119285 DMYQR3A Discovery agent N.A. Investigative [1]
ISIS 119286 DM42LSO Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 9 Investigative Drug(s)

References

1 US patent application no. 6,503,756, Antisense modulation of syntaxin 4 interacting protein expression.