General Information of Drug Therapeutic Target (DTT) (ID: TTKTEAH)

DTT Name Glycerol-3-phosphate dehydrogenase (GPD1)
Synonyms Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; GPDH-C; GPD-C
Gene Name GPD1
DTT Type
Literature-reported target
[1]
BioChemical Class
Short-chain dehydrogenases reductase
UniProt ID
GPDA_HUMAN
TTD ID
T77721
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.1.1.8
Sequence
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHEN
VKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIK
GVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKEL
MQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAK
LFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGP
ETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM
Function
Catalyzes the reversible redox conversion of dihydroxyacetone phosphate (a.k.a. glycerone phosphate, outdated) to sn-glycerol 3-phosphate. serves as a major link between carbohydrate metabolism and lipid metabolism. A major contributor of electrons to the electron transport chain in the mitochondria.
KEGG Pathway
Glycerophospholipid metabolism (hsa00564 )
Reactome Pathway
Synthesis of PA (R-HSA-1483166 )
BioCyc Pathway
MetaCyc:HS09586-MON

References

1 A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishma... Structure. 2000 May 15;8(5):541-52.