Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTKU9YD)

DTT Name	Calcium-activated potassium channel KCa2 (KCNN)
Gene Name	KCNN
DTT Type	Clinical trial target	[1]
BioChemical Class	Voltage-gated ion channel
UniProt ID	NOUNIPROTAC
TTD ID	T95241
Function	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blockedby apamin.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AP-30663	DMJLMEF	Atrial fibrillation	BC81.3	Phase 1/2	[1]
CAD-1883	DMPJLS4	Ataxic disorder	8A03	Phase 1/2	[1]
CAD-1833	DMA1QUC	Essential tremor or related tremors	8A04.1	Phase 1	[2]
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References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)