Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTKW4ML)

DTT Name Caspase 6 messenger RNA (CASP6 mRNA)
Synonyms MCH2 (mRNA); Caspase-6 subunit p18 (mRNA); Caspase-6 subunit p11 (mRNA); CASP-6 (mRNA); Apoptotic protease Mch-2 (mRNA)
Gene Name CASP6
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
CASP6_HUMAN
TTD ID
T25927
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.4.22.59
Sequence
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
Function Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Involved in the activation cascade of caspases responsible for apoptosis execution.
KEGG Pathway
Apoptosis (hsa04210 )
Reactome Pathway
Caspase-mediated cleavage of cytoskeletal proteins (R-HSA-264870 )
Apoptotic cleavage of cellular proteins (R-HSA-111465 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
20 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ac-VEID-CHO DMWOYCZ Discovery agent N.A. Investigative [2]
ISIS 134499 DM90TOR Discovery agent N.A. Investigative [1]
ISIS 134524 DMFCOA5 Discovery agent N.A. Investigative [1]
ISIS 134528 DMYZNIW Discovery agent N.A. Investigative [1]
ISIS 134532 DMRFMVL Discovery agent N.A. Investigative [1]
ISIS 134563 DMWRYA1 Discovery agent N.A. Investigative [1]
ISIS 134564 DM8J24F Discovery agent N.A. Investigative [1]
ISIS 134565 DM9FR3A Discovery agent N.A. Investigative [1]
ISIS 134566 DMCM2S4 Discovery agent N.A. Investigative [1]
ISIS 134583 DM0HWRN Discovery agent N.A. Investigative [1]
ISIS 134601 DMNP8HG Discovery agent N.A. Investigative [1]
ISIS 134602 DMDS4BP Discovery agent N.A. Investigative [1]
ISIS 134603 DM01UDZ Discovery agent N.A. Investigative [1]
ISIS 134604 DM32XGR Discovery agent N.A. Investigative [1]
ISIS 134605 DMCPKV9 Discovery agent N.A. Investigative [1]
ISIS 134606 DM4OF6C Discovery agent N.A. Investigative [1]
ISIS 134607 DMZDJF3 Discovery agent N.A. Investigative [1]
ISIS 134608 DMVX9IT Discovery agent N.A. Investigative [1]
ISIS 134609 DMYODMN Discovery agent N.A. Investigative [1]
Isoquinoline-1,3,4(2H)-trione DMT4RI2 Discovery agent N.A. Investigative [3]
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⏷ Show the Full List of 20 Investigative Drug(s)

References

1 US patent application no. 6,566,135, Antisense modulation of caspase 6 expression.
2 Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91.
3 Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.