Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTL0E3Y)

DTT Name Thioredoxin domain-contained protein 12 (TXNDC12)
Synonyms
hTLP19; UNQ713/PRO1376; Thioredoxin-like protein p19; Thioredoxin domain-containing protein 12; TLP19; Endoplasmic reticulum resident protein 19; Endoplasmic reticulum resident protein 18; ERp19; ERp18; ER protein 19; ER protein 18
Gene Name TXNDC12
DTT Type
Literature-reported target
 [1]
UniProt ID
TXD12_HUMAN
TTD ID
T36419
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.8.4.2
Sequence
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI
IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP
SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
Function Possesses significant protein thiol-disulfide oxidase activity.
KEGG Pathway
Glutathione metabolism (hsa00480 )
Metabolic pathways (hsa01100 )

References

1 Thioredoxin domain-containing protein 12 from Oplegnathus fasciatus: Molecular characterization, expression against immune stimuli, and biological ... Fish Shellfish Immunol. 2016 Jul;54:11-21.