Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTL2PXZ)

DTT Name	Vacuolar-type proton ATPase catalytic A (v-ATPase-A)
Synonyms	Vacuolar proton pump subunit alpha; Vacuolar ATPase isoform VA68; VPP2; V-ATPase subunit A; V-ATPase 69 kDa subunit; ATP6V1A1; ATP6V1A; ATP6A1
Gene Name	ATP6V1A
DTT Type	Literature-reported target	[1]
BioChemical Class	Acid anhydrides hydrolase
UniProt ID	VATA_HUMAN
TTD ID	T16731
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 7.1.2.2
Sequence	MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGD MATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPR GVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIA PPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPC VQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDG KVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALRE ISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDP VTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAK EILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGM LSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSD YAQLLEDMQNAFRSLED
Function	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
KEGG Pathway	Oxidative phosphorylation (hsa00190 ) Metabolic pathways (hsa01100 ) Phagosome (hsa04145 ) Synaptic vesicle cycle (hsa04721 ) Collecting duct acid secretion (hsa04966 ) Vibrio cholerae infection (hsa05110 ) Epithelial cell signaling in Helicobacter pylori infection (hsa05120 ) Rheumatoid arthritis (hsa05323 )
Reactome Pathway	Insulin receptor recycling (R-HSA-77387 ) Transferrin endocytosis and recycling (R-HSA-917977 ) ROS production in response to bacteria (R-HSA-1222556 )
BioCyc Pathway	MetaCyc:HS03781-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

1 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cruentaren	DM8AR0E	Fungal infection	1F29-1F2F	Preclinical	[1]
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References

1	Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22.