Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTL4FMB)

DTT Name TWIK-related acid-sensitive potassium channel 3 (TASK3)
Synonyms Two pore potassium channel KT3.2; TWIK-related acid-sensitive K+ channel 3; KCNK9; Acid-sensitive potassium channel protein TASK-3
Gene Name KCNK9
DTT Type
Literature-reported target
 [1]
UniProt ID
KCNK9_HUMAN
TTD ID
T57613
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYR
QLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPL
TLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQ
CEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLN
LVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCT
CYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHS
FTDHQRLMKRRKSV
Function pH-dependent, voltage-insensitive, background potassium channel protein.
KEGG Pathway
Aldosterone synthesis and secretion (hsa04925 )
Reactome Pathway
Phase 4 - resting membrane potential (R-HSA-5576886 )
TWIK-releated acid-sensitive K+ channel (TASK) (R-HSA-1299316 )

The Drug Transporter (DTP) Role of This DTT

DTT DTP Name Potassium channel subfamily K member 9 (KCNK9) DTP Info
Gene Name KCNK9

References

1 Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7803-7.