Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLBYH1)

DTT Name Guanylate cyclase soluble beta-1 (GUCY1B1)
Synonyms Soluble guanylate cyclase small subunit; Guanylate cyclase soluble subunit beta-3; Guanylate cyclase soluble subunit beta-1; GUCY1B3; GUCSB3; GUC1B3; GCS-beta-3; GCS-beta-1
Gene Name GUCY1B1
DTT Type
Clinical trial target
 [1]
BioChemical Class
Phosphorus-oxygen lyase
UniProt ID
GCYB1_HUMAN
TTD ID
T61581
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 4.6.1.2
Sequence
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
Function Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
KEGG Pathway
Purine metabolism (hsa00230 )
cGMP-PKG signaling pathway (hsa04022 )
Vascular smooth muscle contraction (hsa04270 )
Gap junction (hsa04540 )
Platelet activation (hsa04611 )
Circadian entrainment (hsa04713 )
Long-term depression (hsa04730 )
Oxytocin signaling pathway (hsa04921 )
Salivary secretion (hsa04970 )
Reactome Pathway
Nitric oxide stimulates guanylate cyclase (R-HSA-392154 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cinaciguat DMGEAM6 Acute decompensated heart failure BD1Z Phase 2 [2]
Vericigiuat DM104SP Heart failure BD10-BD13 Phase 2 [1]
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1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
RIG-200 DMLQD6F Hypertension BA00-BA04 Discontinued in Phase 1 [3]
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References

1 Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES). Eur J Heart Fail. 2014 Sep;16(9):1026-38.
2 Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Circulation. 2009 Jun 2;119(21):2781-8.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015