General Information of Drug Therapeutic Target (DTT) (ID: TTLC8E1)

DTT Name Haptoglobin (HP)
Synonyms Haptoglobin beta chain; HP
Gene Name HP
DTT Type
Clinical trial target
[1]
BioChemical Class
Peptidase
UniProt ID
HPT_HUMAN
TTD ID
T17710
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
Function
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. {ECO:0000269|PubMed:21248165}.
Reactome Pathway
Neutrophil degranulation (R-HSA-6798695 )
Scavenging of heme from plasma (R-HSA-2168880 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
AT1001 DMRV4DT Autoimmune diabetes 5A10 Phase 3 [1]
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References

1 Zonulin, regulation of tight junctions, and autoimmune diseases