Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLQUZS)

DTT Name Cystathionine gamma-lyase (CTH)
Synonyms Gamma-cystathionase; Cysteine-protein sulfhydrase
Gene Name CTH
DTT Type
Patented-recorded target
 [1]
UniProt ID
CGL_HUMAN
TTD ID
T12241
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 4.4.1.1
Sequence
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG
DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQH
ELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVL
KNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
Function
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.
KEGG Pathway
Glycine, serine and threonine metabolism (hsa00260 )
Cysteine and methionine metabolism (hsa00270 )
Selenocompound metabolism (hsa00450 )
Metabolic pathways (hsa01100 )
Biosynthesis of amino acids (hsa01230 )
Reactome Pathway
Cysteine formation from homocysteine (R-HSA-1614603 )
Metabolism of ingested SeMet, Sec, MeSec into H2Se (R-HSA-2408508 )
Degradation of cysteine and homocysteine (R-HSA-1614558 )
BioCyc Pathway
MetaCyc:HS04050-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
5-Hydrazino-1H-tetrazole DMOIKB3 N. A. N. A. Patented [2]
AKOS003197197 DM0P2U3 N. A. N. A. Patented [2]
Hydrazinoacetic acid DMEQBTO N. A. N. A. Patented [2]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
propargylglycine DMVRWL6 Discovery agent N.A. Investigative [1]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1444).
2 Cystathionine--lyase (CSE) inhibitors. US9725426.