Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLXKZR)

DTT Name	Prostacyclin synthase (PTGIS)
Synonyms	Prostaglandin I2 synthase; PTGIS
Gene Name	PTGIS
DTT Type	Literature-reported target	[1]
BioChemical Class	Intramolecular oxidoreductases
UniProt ID	PTGIS_HUMAN
TTD ID	T83979
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 5.3.99.4
Sequence	MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR YGFGLMQPEHDVPVRYRIRP
Function	Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
KEGG Pathway	Arachidonic acid metabolism (hsa00590 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Synthesis of bile acids and bile salts via 24-hydroxycholesterol (R-HSA-193775 ) Synthesis of bile acids and bile salts via 27-hydroxycholesterol (R-HSA-193807 ) Nicotinamide salvaging (R-HSA-197264 ) Eicosanoids (R-HSA-211979 ) Sterols are 12-hydroxylated by CYP8B1 (R-HSA-211994 ) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (R-HSA-2162123 ) Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (R-HSA-193368 )
BioCyc Pathway	MetaCyc:HS04738-MON

References

1	Role of prostacyclin synthase in carcinogenesis. Prostaglandins Other Lipid Mediat. 2017 Nov;133:49-52.