Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTM642F)

DTT Name	Adrenomedullin 2 (ADM2)
Synonyms	Intermedin; ADM2
Gene Name	ADM2
DTT Type	Literature-reported target	[1]
BioChemical Class	Adrenomedullin
UniProt ID	ADM2_HUMAN
TTD ID	T68208
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MARIPTAALGCISLLCLQLPGSLSRSLGGDPRPVKPREPPARSPSSSLQPRHPAPRPVVW KLHRALQAQRGAGLAPVMGQPLRDGGRQHSGPRRHSGPRRTQAQLLRVGCVLGTCQVQNL SHRLWQLMGPAGRQDSAPVDPSSPHSYG
Function	IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
KEGG Pathway	Neuroactive ligand-receptor interaction (hsa04080 ) Vascular smooth muscle contraction (hsa04270 )
Reactome Pathway	Calcitonin-like ligand receptors (R-HSA-419812 ) ADORA2B mediated anti-inflammatory cytokines production (R-HSA-9660821 ) G alpha (s) signalling events (R-HSA-418555 )

References

1	Adrenomedullin2 (ADM2)/Intermedin (IMD): A Potential Role in the Pathophysiology of Preeclampsia. J Clin Endocrinol Metab. 2016 Nov;101(11):4478-4488.