Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTM7D9O)

DTT Name Annexin II receptor (ANXA2R)
Synonyms Annexin2 receptor; AXIIR; ANXA2R
Gene Name ANXA2R
DTT Type
Literature-reported target
 [1]
UniProt ID
AX2R_HUMAN
TTD ID
T80966
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQHFLGCVKRAWDSAEVAPEPQPPPIVSSEDRGPWPLPLYPVLGEYSLDSCDLGLLSSP
CWRLPGVYWQNGLSPGVQSTLEPSTAKPTEFSWPGTQKQQEAPVEEVGQAEEPDRLRLQQ
LPWSSPLHPWDRQQDTEVCDSGCLLERRHPPALQPWRHLPGFSDCLEWILRVGFAAFSVL
WACCSRICGAKQP
Function May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

References

1 SiRNA directed against annexin II receptor inhibits angiogenesis via suppressing MMP2 and MMP9 expression. Cell Physiol Biochem. 2015;35(3):875-84.