Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMBO1Z)

• DTT Name: Cyclin-dependent kinase (CDK)
• Synonyms: Cyclin dependent kinase
• Gene Name: CDK
• DTT Type: Clinical trial target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T70508

Molecular Interaction Atlas (MIA) of This DTT

4 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flavopiridol	DMKSUOI	Acute myeloid leukaemia	2A60	Phase 2	[2]
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[1]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[3]
PF-06873600	DMRZHV6	Breast cancer	2C60-2C65	Phase 1	[3]

4 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indole-based analog 12	DM1CNRH	N. A.	N. A.	Patented	[4]
PMID26161698-Compound-10	DMXVCHZ	N. A.	N. A.	Patented	[4]
PMID26161698-Compound-44	DM8UPO3	N. A.	N. A.	Patented	[4]
Purine derivative 4	DMYD5SQ	N. A.	N. A.	Patented	[4]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BS-194	DMLXFHD	Solid tumour/cancer	2A00-2F9Z	Investigative	[5]

References

• [1] Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.Clin Cancer Res. 2009 Jun 1;15(11):3716-24.
• [2] Pharma & Vaccines. Product Development Pipeline. April 29 2009.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8176).