| DTT Name |
HUMAN NF-kappa-B-activating kinase (TBK1)
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| Synonyms |
TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK |
| Gene Name |
TBK1
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| BioChemical Class |
Kinase
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 2.7.11.1
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| Sequence |
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
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| Function |
Human protein TANK binding kinase 1 interacts with SARS-CoV-2 Nsp13 protein with high significance, which indicates TBK1 as a potential therapeutic target. |
| KEGG Pathway |
- Ras signaling pathway (hsa04014 )
- Mitophagy - animal (hsa04137 )
- Autophagy - animal (hsa04140 )
- Toll-like receptor signaling pathway (hsa04620 )
- NOD-like receptor signaling pathway (hsa04621 )
- RIG-I-like receptor signaling pathway (hsa04622 )
- Cytosolic DNA-sensing pathway (hsa04623 )
- IL-17 signaling pathway (hsa04657 )
- Alcoholic liver disease (hsa04936 )
- Amyotrophic lateral sclerosis (hsa05014 )
- Pathways of neurodegeneration - multiple diseases (hsa05022 )
- Shigellosis (hsa05131 )
- Yersinia infection (hsa05135 )
- Hepatitis C (hsa05160 )
- Hepatitis B (hsa05161 )
- Measles (hsa05162 )
- Human cytomegalovirus infection (hsa05163 )
- Influenza A (hsa05164 )
- Human papillomavirus infection (hsa05165 )
- Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
- Herpes simplex virus 1 infection (hsa05168 )
- Epstein-Barr virus infection (hsa05169 )
- Human immunodeficiency virus 1 infection (hsa05170 )
- Coronavirus disease - COVID-19 (hsa05171 )
- Lipid and atherosclerosis (hsa05417 )
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| Reactome Pathway |
- DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928 )
- Regulation of innate immune responses to cytosolic DNA (R-HSA-3134975 )
- STAT6-mediated induction of chemokines (R-HSA-3249367 )
- IRF3-mediated induction of type I IFN (R-HSA-3270619 )
- Interleukin-37 signaling (R-HSA-9008059 )
- TICAM1-dependent activation of IRF3/IRF7 (R-HSA-9013973 )
- TRAF3-dependent IRF activation pathway (R-HSA-918233 )
- TRAF6 mediated IRF7 activation (R-HSA-933541 )
- Negative regulators of DDX58/IFIH1 signaling (R-HSA-936440 )
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964 )
- Potential therapeutics for SARS (R-HSA-9679191 )
- SARS-CoV-2 activates/modulates innate and adaptive immune responses (R-HSA-9705671 )
- IRF3 mediated activation of type 1 IFN (R-HSA-1606341 )
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