Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMQDZ5)

DTT Name	Mannose binding protein (MBL2)
Synonyms	Mannosebinding protein C; Mannosebinding lectin; Mannanbinding protein; MBPC; MBP1; MBL2; Collectin1
Gene Name	MBL2
DTT Type	Literature-reported target	[1]
UniProt ID	MBL2_HUMAN
TTD ID	T32699
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKG EPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMA RIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKE EAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSH LAVCEFPI
Function	Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. {ECO:0000269\|PubMed:14515269}.
KEGG Pathway	Phagosome (hsa04145 ) Complement and coagulation cascades (hsa04610 ) Staphylococcus aureus infection (hsa05150 ) Coronavirus disease - COVID-19 (hsa05171 )
Reactome Pathway	Initial triggering of complement (R-HSA-166663 ) SARS-CoV-2 activates/modulates innate and adaptive immune responses (R-HSA-9705671 ) Lectin pathway of complement activation (R-HSA-166662 )

References

1	Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury. J Cereb Blood Flow Metab. 2017 Mar;37(3):938-950.