Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMTS9H)

DTT Name Claudin-4 (CLDN4)
Synonyms WilliamsBeuren syndrome chromosomal region 8 protein; Clostridium perfringens enterotoxin receptor; Claudin4; CPEreceptor; CPER; CLDN4
Gene Name CLDN4
DTT Type
Literature-reported target
 [1]
UniProt ID
CLD4_HUMAN
TTD ID
T51270
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG
QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIV
AGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGL
LCCNCPPRTDKPYSAKYSAARSAAASNYV
Function Plays a major role in tight junction-specific obliteration of the intercellularspace.
KEGG Pathway
Cell adhesion molecules (hsa04514 )
Tight junction (hsa04530 )
Leukocyte transendothelial migration (hsa04670 )
Pathogenic Escherichia coli infection (hsa05130 )
Hepatitis C (hsa05160 )
Reactome Pathway
Tight junction interactions (R-HSA-420029 )

References

1 Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology. 2001 Sep;121(3):678-84.