Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMXD0O)

• DTT Name: Coagulation factor XII (F12)
• Synonyms: Hageman factor; HAF
• Gene Name: F12
• DTT Type: Clinical trial target; [1]
• UniProt ID: FA12_HUMAN
• TTD ID: T38509
• EC Number: EC 3.4.21.38
• Sequence:
  MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
  CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
  CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
  NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
  WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
  AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
  QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
  EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
  YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
  SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
  DVAYYLAWIREHTVS
• KEGG Pathway: Complement and coagulation cascades (hsa04610)
• Reactome Pathway:
  Defective factor XII causes hereditary angioedema (R-HSA-9657688)
  Defective SERPING1 causes hereditary angioedema (R-HSA-9657689)
  Intrinsic Pathway of Fibrin Clot Formation (R-HSA-140837)

Molecular Interaction Atlas (MIA) of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CSL312	DMV574J	Hereditary angioedema	4A00.14	Phase 3	[1]
ION547	DMVNKNJ	Thrombosis	DB61-GB90	Phase 1	[2]

References

• [1] Clinical pipeline report, company report or official report of CSL Behring.
• [2] ClinicalTrials.gov (NCT04934891) A Double-Blind, Placebo-Controlled, Dose-Escalation Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ION547 Administered Subcutaneously to Healthy Subjects. U.S.National Institutes of Health.