Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTNA5ZS)

DTT Name	Cholesterol absorption (Chole absorp)
Gene Name	Chole absorp
DTT Type	Clinical trial target	[1]
UniProt ID	NOUNIPROTAC
TTD ID	T59870

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KT6-971	DM08F12	Hypercholesterolaemia	5C80.0	Phase 2	[1]
MD-0727	DM5DSGJ	Hypercholesterolaemia	5C80.0	Phase 2	[2]
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2 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SCH-48461	DM28AFU	Hyperlipidaemia	5C80	Discontinued in Phase 2	[3]
Tiqueside	DMUJ2X6	Hyperlipidaemia	5C80	Discontinued in Phase 2	[4]
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References

1	Intestinal and Hepatic Niemann-Pick C1-Like 1. Correction in: Diabetes Metab J. 2013 December; 37(6): 486-487.
2	Th-P16:297 Early clinical characterization of MD-0727, a novel cholesterol absorption inhibitor, in healthy subjects. Atherosclerosis Supplements Volume 7, Issue 3, 2006, Pages 558-559.
3	Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461. Atherosclerosis. 1995 May;115(1):45-63.
4	Inhibiting cholesterol absorption with CP-88,818 (beta-tigogenin cellobioside; tiqueside): studies in normal and hyperlipidemic subjects. J Cardiovasc Pharmacol. 1997 Jul;30(1):55-60.