Details of the Drug Therapeutic Target (DTT) | DrugMAP

General Information of Drug Therapeutic Target (DTT) (ID: TTNGCRK)

DTT Name	Aquaporin-7 (AQP7)
Synonyms	Aquaporin-7-like; Aquaporin adipose; Aquaglyceroporin-7; AQPap; AQP7L; AQP-7
Gene Name	AQP7
DTT Type	Literature-reported target				[1]
BioChemical Class	Major intrinsic protein
UniProt ID	AQP7_HUMAN
TTD ID	T94438
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVL NKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQF LGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTG MLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIA GWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITV LPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF
Function	Forms a channel for water and glycerol.
KEGG Pathway	PPAR signaling pathway (hsa03320 ) Regulation of lipolysis in adipocytes (hsa04923 )
Reactome Pathway	Passive transport by Aquaporins (R-HSA-432047 ) Transport of glycerol from adipocytes to the liver by Aquaporins (R-HSA-432030 )
BioCyc Pathway	MetaCyc:ENSG00000165269-MON

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Aquaporin adipose (AQP7) DME Info

Gene Name

AQP7

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycerol phenylbutyrate	DMDGRQO	Hepatic encephalopathy	DB99.5	Approved	[2]
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References

1	Pancreatic Aquaporin-7: A Novel Target for Anti-diabetic Drugs Front Chem. 2018 Apr 5;6:99.
2	Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. Int J Androl. 2010 Aug 1;33(4):629-41.