Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTNOJIZ)

DTT Name	Trefoil factor-1 (TFF1)
Synonyms	hP1.A; Trefoil factor 1; Protein pS2; Polypeptide P1.A; PS2; PNR-2; Breast cancer estrogen-inducible protein; BCEI
Gene Name	TFF1
DTT Type	Clinical trial target	[1]
UniProt ID	TFF1_HUMAN
TTD ID	T38159
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDD TVRGVPWCFYPNTIDVPPEEECEF
Function	May inhibit the growth of calcium oxalate crystals in urine. Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
KEGG Pathway	Estrogen signaling pathway (hsa04915 )
Reactome Pathway	Estrogen-dependent gene expression (R-HSA-9018519 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AG-013	DMGC970	Oral mucositis	DA01.11	Phase 2/3	[1]
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References

1	AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis. Oral Oncol. 2010 Jul;46(7):564-70.