General Information of Drug Therapeutic Target (DTT) (ID: TTNOSTX)

DTT Name Urokinase plasminogen receptor (PLAUR)
Synonyms UPAR; U-PAR; Monocyte activation antigen Mo3; MO3
Gene Name PLAUR
DTT Type
Literature-reported target
[1]
UniProt ID
UPAR_HUMAN
TTD ID
T36147
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
KEGG Pathway
Complement and coagulation cascades (hsa04610 )
Proteoglycans in cancer (hsa05205 )
Reactome Pathway
Neutrophil degranulation (R-HSA-6798695 )
Dissolution of Fibrin Clot (R-HSA-75205 )
Attachment of GPI anchor to uPAR (R-HSA-162791 )

References

1 Could soluble urokinase plasminogen receptor (suPAR) be used as a diagnostic biomarker for ventilator-associated pneumonia Clin Respir J. 2017 Nov;11(6):925-930.