Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TTNQ760)
| DTT Name | Polyamine oxidase (PAOX) | ||||
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| Synonyms | Peroxisomal N(1)acetylspermine/spermidine oxidase; PAOX | ||||
| Gene Name | PAOX | ||||
| DTT Type |
Literature-reported target
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[1] | |||
| BioChemical Class |
CH-NH donor oxidoreductase
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| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| EC Number |
EC 1.5.3.13
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| Sequence |
MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCF
GGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGA SVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLK LAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGYQGLTNCMMAALPEDT VVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFLREHLDTFF DPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSPLEDAAPELQDAW FRKLIGFVVLPAFASVHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGNPRLPAPK SVLRSRWHSAPYTRGSYSYVAVGSTGGDLDLLAQPLPADGAGAQLQILFAGEATHRTFYS TTHGALLSGWREADRLLSLWAPQVQQPRPRL |
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| Function |
Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
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| KEGG Pathway | |||||
| Reactome Pathway | |||||
The Drug-Metabolizing Enzyme (DME) Role of This DTT
| DTT DME Name | Polyamine oxidase (PAOX) | |||||||||||||||||||||||||||
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| Gene Name | PAOX | |||||||||||||||||||||||||||
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1 Discontinued Drug(s) Metabolized by This DTT
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