Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTO32GK)

DTT Name P-glycoprotein (P-GP)
Gene Name P-GP
DTT Type
Discontinued target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T04183

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
S-9788 DMER3I9 Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [2]
XR-9051 DMCK210 Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [1]
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References

1 Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol. 2000 Sep;58(3):624-32.
2 In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells-reversal of multidrug resistance by sera from phase I-treated patients. Cancer Chemother Pharmacol. 1995;36(3):195-203.