Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTO7014)

DTT Name FasL messenger RNA (FASLG mRNA)
Synonyms
Tumor necrosis factor ligand superfamily member 6 (mRNA); TNFSF6 (mRNA); FasL (mRNA); Fas ligand (mRNA); FAS antigen ligand (mRNA); CD95L (mRNA); CD95-L (mRNA); CD95 ligand (mRNA); CD178 antigen (mRNA); CD178 (mRNA); Apoptosis antigen ligand (mRNA); APTL (mRNA); APT1LG1 (mRNA)
Gene Name FASLG
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
TNFL6_HUMAN
TTD ID
T37077
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPP
PPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQ
MHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGG
LVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWA
RSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL
Function
Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
Ras signaling pathway (hsa04014 )
Cytokine-cytokine receptor interaction (hsa04060 )
FoxO signaling pathway (hsa04068 )
PI3K-Akt signaling pathway (hsa04151 )
Apoptosis (hsa04210 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Neurotrophin signaling pathway (hsa04722 )
Non-alcoholic fatty liver disease (NAFLD) (hsa04932 )
Type I diabetes mellitus (hsa04940 )
Chagas disease (American trypanosomiasis) (hsa05142 )
African trypanosomiasis (hsa05143 )
Hepatitis B (hsa05161 )
Measles (hsa05162 )
Influenza A (hsa05164 )
Herpes simplex infection (hsa05168 )
Pathways in cancer (hsa05200 )
Proteoglycans in cancer (hsa05205 )
Autoimmune thyroid disease (hsa05320 )
Allograft rejection (hsa05330 )
Graft-versus-host disease (hsa05332 )
Reactome Pathway
FasL/ CD95L signaling (R-HSA-75157 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 16179 DMOTMVP Discovery agent N.A. Investigative [1]
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References

1 US patent application no. 6,204,055, Antisense inhibition of Fas mediated signaling.