Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOBVIN)

DTT Name	Secretin receptor (SCT)
Synonyms	SCTR; SCT-R; SCT
Gene Name	SCT
DTT Type	Successful target	[1]
BioChemical Class	GPCR secretin
UniProt ID	SECR_HUMAN
TTD ID	T46904
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAPRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLREGARLQRLLQGLVGKRSEQ DAENSMAWTRLSAGLLCPSGSNMPILQAWMPLDGTWSPWLPPGPMVSEPAGAAAEGTLRP R
Function	This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
KEGG Pathway	Neuroactive ligand-receptor interaction (hsa04080 ) Pancreatic secretion (hsa04972 ) Bile secretion (hsa04976 )
Reactome Pathway	Glucagon-type ligand receptors (R-HSA-420092 ) G alpha (s) signalling events (R-HSA-418555 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Secretin	DMDKE4N	Gastrinoma	2C10.1	Approved	[1]
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References

1	False-positive secretin stimulation test for gastrinoma associated with the use of proton pump inhibitor therapy. Clin Gastroenterol Hepatol. 2009 May;7(5):600-2.