Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOI1RM)

• DTT Name: A proliferation-inducing ligand (APRIL)
• Synonyms: ZTNF2; UNQ383/PRO715; Tumor necrosis factor ligand superfamily member 13; TRDL-1; TNF-related death ligand 1; TNF- and APOL-related leukocyte expressed ligand 2; TALL2; TALL-2; CD256
• Gene Name: TNFSF13
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Cytokine: tumor necrosis factor
• UniProt ID: TNF13_HUMAN
• TTD ID: T14676
• Sequence:
  MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
  EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL
  VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
  VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
  HGTFLGFVKL
• Function: Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA.
• KEGG Pathway:
  Cytokine-cytokine receptor interaction (hsa04060)
  Intestinal immune network for IgA production (hsa04672)
  Rheumatoid arthritis (hsa05323)
• Reactome Pathway:
  TNFs bind their physiological receptors (R-HSA-5669034)
  HuR (ELAVL1) binds and stabilizes mRNA (R-HSA-450520)

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atacicept	DM8GFEV	Lymphoma	2A80-2A86	Phase 3	[1]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Rheumatoid arthritis	FA20	Synovial tissue	3.53E-01	-0.2	-0.46

References

• [1] Atacicept: a new B lymphocyte-targeted therapy for multiple sclerosis. Nervenarzt. 2009 Dec;80(12):1462-72.