Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOM5H4)

DTT Name Vascular endothelial growth factor D (VEGFD)
Synonyms c-Fos-induced growth factor; VEGFD; VEGF-D; FIGF
Gene Name VEGFD
DTT Type
Clinical trial target
 [1]
BioChemical Class
Growth factor
UniProt ID
VEGFD_HUMAN
TTD ID
T63803
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSE
DWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEV
ASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVP
VKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHSKKLCPIDMLWDSNKCKCVLQEE
NPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPCPKDLIQHPKNCSCFECKESLETC
CQKHKLFHPDTCSCEDRCPFHTRPCASGKTACAKHCRFPKEKRAAQGPHSRKNP
Function
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formationof the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
KEGG Pathway
Ras signaling pathway (hsa04014 )
Rap1 signaling pathway (hsa04015 )
Cytokine-cytokine receptor interaction (hsa04060 )
PI3K-Akt signaling pathway (hsa04151 )
Focal adhesion (hsa04510 )
Pathways in cancer (hsa05200 )
Reactome Pathway
VEGF ligand-receptor interactions (R-HSA-194313 )
VEGF binds to VEGFR leading to receptor dimerization (R-HSA-195399 )
Platelet degranulation (R-HSA-114608 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
OPT-302 DMS4XFI Diabetic macular edema 9B71.02 Phase 2 [2]
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2 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
EG-011 DM17GMN Angina pectoris BA40 Discontinued in Phase 1/2 [1]
EG-016 DM7JMVR Peripheral vascular disease BD4Z Discontinued in Phase 1/2 [1]
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References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030807)
2 Clinical pipeline report, company report or official report of Opthea.