Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TTOM97J)
| DTT Name | Cytohesin-2 messenger RNA (CYTH2 mRNA) | ||||
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| Synonyms |
Protein ARNO (mRNA); PSCD2L (mRNA); PSCD2 (mRNA); PH, SEC7 and coiled-coil domain-containing protein 2 (mRNA); Cytohesin-2 (mRNA); CYTH2 (mRNA); ARNO (mRNA); ARF nucleotide-binding site opener (mRNA); ARF exchange factor (mRNA)
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| Gene Name | CYTH2 | ||||
| DTT Type |
Literature-reported target
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[1] | |||
| BioChemical Class |
mRNA target
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| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| Sequence |
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP |
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| Function |
Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. Acts as a guanine-nucleotide exchange factor (GEF).
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| KEGG Pathway | |||||
| Reactome Pathway | |||||
Molecular Interaction Atlas (MIA) of This DTT
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9 Investigative Drug(s) Targeting This DTT
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