Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTON5JB)

• DTT Name: MADH6 messenger RNA (MADH6 mRNA)
• Synonyms: hSMAD6 (mRNA); Smad6 (mRNA); SMAD family member 6 (mRNA); SMAD 6 (mRNA); Mothers against decapentaplegic homolog 6 (mRNA); Mothers against DPP homolog 6 (mRNA); MADH6 (mRNA); MAD homolog 6 (mRNA)
• Gene Name: SMAD6
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: SMAD6_HUMAN
• TTD ID: T92714
• Sequence:
  MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEV
  RPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESD
  CETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLL
  KRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVE
  LKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSY
  TETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDL
  PQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAP
  GGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQF
  ITSCPCWLEILLNNPR
• Function: Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. Acts as a mediator of TGF-beta and BMP antiflammatory activity.
• KEGG Pathway:
  Endocytosis (hsa04144)
  TGF-beta signaling pathway (hsa04350)
• Reactome Pathway:
  RUNX2 regulates bone development (R-HSA-8941326)
  Signaling by BMP (R-HSA-201451)

Molecular Interaction Atlas (MIA) of This DTT

11 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 101952	DMS6JD4	Discovery agent	N.A.	Investigative	[1]
ISIS 101960	DMEWXR2	Discovery agent	N.A.	Investigative	[1]
ISIS 101983	DMV9PI7	Discovery agent	N.A.	Investigative	[1]
ISIS 101984	DMYZ5CX	Discovery agent	N.A.	Investigative	[1]
ISIS 101985	DM8CN2M	Discovery agent	N.A.	Investigative	[1]
ISIS 101986	DM5PTQX	Discovery agent	N.A.	Investigative	[1]
ISIS 101987	DMWCK8Q	Discovery agent	N.A.	Investigative	[1]
ISIS 101995	DM3EMLB	Discovery agent	N.A.	Investigative	[1]
ISIS 101996	DM5APGL	Discovery agent	N.A.	Investigative	[1]
ISIS 101997	DMUZJCD	Discovery agent	N.A.	Investigative	[1]
ISIS 101998	DMEH6G1	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 6,277,636, Antisense inhibition of MADH6 expression.