Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOVUPC)

• DTT Name: Similar to dipeptidyl aminopeptidase-like protein (DPP10)
• Synonyms: KIAA1492; Inactive dipeptidyl peptidase 10; Dipeptidyl peptidase-like protein 2; Dipeptidyl peptidase X; Dipeptidyl peptidase IV-related protein 3; DPRP3; DPRP-3; DPP X; DPL2
• Gene Name: DPP10
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Prolyl oligopeptidase family
• UniProt ID: DPP10_HUMAN
• TTD ID: T43102
• Sequence:
  MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDE
  LTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENT
  TFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVL
  QYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHI
  AHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLY
  GPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKY
  EMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTS
  GNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDA
  SFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHI
  DDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFD
  GRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMI
  LKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENIL
  IIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDC
  LKEEISVLPQEPEEDE
• Function: Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity.

References

• [1] Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet. 2003 Nov;35(3):258-63.