General Information of Drug Therapeutic Target (DTT) (ID: TTOZAFI)

DTT Name Gap junction delta-2 protein (Cx36)
Synonyms GJA9; Connexin-36
Gene Name GJD2
DTT Type
Literature-reported target
[1]
BioChemical Class
Gap junction-forming connexin
UniProt ID
CXD2_HUMAN
TTD ID
T88104
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP
GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP
PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG
LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV
ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNK
DLPRVSVPNFGRTQSSDSAYV
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
KEGG Pathway
Gap junction (hsa04540 )
Reactome Pathway
Gap junction assembly (R-HSA-190861 )
Electric Transmission Across Gap Junctions (R-HSA-112303 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
octanol DMBGHPE Discovery agent N.A. Investigative [1]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 724).