General Information of Drug Therapeutic Target (DTT) (ID: TTOZAX0)

DTT Name Leukosialin (SPN)
Synonyms Sialophorin; Leukocyte sialoglycoprotein; Leucocyte sialoglycoprotein; Galactoglycoprotein; GPL115; GALGP; CD43 antigen; CD43
Gene Name SPN
DTT Type
Literature-reported target
[1]
UniProt ID
LEUK_HUMAN
TTD ID
T97201
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATLLLLLGVLVVSPDALGSTTAVQTPTSGEPLVSTSEPLSSKMYTTSITSDPKADSTGD
QTSALPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPI
TANSLGSHTVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSK
GTSGPPVTMATDSLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTMMSPTTSTNA
STVPFRNPDENSRGMLPVAVLVALLAVIVLVALLLLWRRRQKRRTGALVLSRGGKRNGVV
DAWAGPAQVPEEGAVTVTVGGSGGDKGSGFPDGEGSSRRPTLTTFFGRRKSRQGSLAMEE
LKSGSGPSLKGEEEPLVASEDGAVDAPAPDEPEGGDGAAP
Function
Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1. Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration.
KEGG Pathway
Cell adhesion molecules (hsa04514 )
Reactome Pathway
Basigin interactions (R-HSA-210991 )
Cell surface interactions at the vascular wall (R-HSA-202733 )

References

1 Anti-CD43 inhibits monocyte-endothelial adhesion in inflammation and atherogenesis. Blood. 1997 Nov 1;90(9):3587-94.