Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTP6BIJ)

DTT Name	Transgelin-2 (TAGLN2)
Synonyms	SM22-alpha homolog; KIAA0120; Epididymis tissue protein Li 7e
Gene Name	TAGLN2
DTT Type	Literature-reported target	[1]
BioChemical Class	Calponin family
UniProt ID	TAGL2_HUMAN
TTD ID	T93147
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT NRGASQAGMTGYGMPRQIL
Function	cytosol, extracellular exosome, extracellular region, vesicle, cadherin binding, epithelial cell differentiation, platelet degranulation.
Reactome Pathway	Platelet degranulation (R-HSA-114608 )

References

1	Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer. J Exp Clin Cancer Res. 2018 Jul 24;37(1):166.