Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTPAFR9)

• DTT Name: Ketohexokinase (KHK)
• Synonyms: Hepatic fructokinase
• Gene Name: KHK
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Kinase
• UniProt ID: KHK_HUMAN
• TTD ID: T79326
• EC Number: EC 2.7.1.3
• Sequence:
  MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
  GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
  SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
  QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
  HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
• Function: Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
• KEGG Pathway:
  Fructose and mannose metabolism (hsa00051)
  Metabolic pathways (hsa01100)
• Reactome Pathway:
  Fructose catabolism (R-HSA-70350)
  Essential fructosuria (R-HSA-5657562)
• BioCyc Pathway: MetaCyc:HS06437-MON

References

• [1] Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). J Med Chem. 2017 Sep 28;60(18):7835-7849.