Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTPJ9XK)

DTT Name hnRNP A1 messenger RNA (HNRNPA1 mRNA)
Synonyms hnRNP core protein A1 (mRNA); hnRNP A1 (mRNA); Single-strand RNA-binding protein (mRNA); Heterogeneous nuclear ribonucleoprotein A1 (mRNA); Helix-destabilizing protein (mRNA); HNRPA1 (mRNA)
Gene Name HNRNPA1
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
ROA1_HUMAN
TTD ID
T12052
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFV
TYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHH
LRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKA
LSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGS
GDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGG
GSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGS
SSSSSYGSGRRF
Function May bind to specific miRNA hairpins. Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.
KEGG Pathway
Spliceosome (hsa03040 )
Reactome Pathway
mRNA Splicing - Major Pathway (R-HSA-72163 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
15 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 111992 DMNIBTG Discovery agent N.A. Investigative [1]
ISIS 111993 DMVMDAZ Discovery agent N.A. Investigative [1]
ISIS 111997 DMSXTRI Discovery agent N.A. Investigative [1]
ISIS 112000 DM1NHJ8 Discovery agent N.A. Investigative [1]
ISIS 112001 DM2K74C Discovery agent N.A. Investigative [1]
ISIS 112002 DMPROW5 Discovery agent N.A. Investigative [1]
ISIS 112003 DMHRLYJ Discovery agent N.A. Investigative [1]
ISIS 112004 DMRJ1L6 Discovery agent N.A. Investigative [1]
ISIS 112005 DMDZY8F Discovery agent N.A. Investigative [1]
ISIS 112019 DMN6IBS Discovery agent N.A. Investigative [1]
ISIS 112020 DMO2FY8 Discovery agent N.A. Investigative [1]
ISIS 112021 DM0E1SH Discovery agent N.A. Investigative [1]
ISIS 112022 DM7R53M Discovery agent N.A. Investigative [1]
ISIS 112023 DM5F4Q6 Discovery agent N.A. Investigative [1]
ISIS 112024 DMVLHN9 Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 15 Investigative Drug(s)

References

1 US patent application no. 6,165,789, Antisense modulation of hnRNP A1 expression.