Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTPOI4B)

DTT Name Acetyl-CoA:lyso-PAF acetyltransferase (PCAT)
Synonyms
Lysophosphatidylcholine acyltransferase; LysoPC acyltransferase; LysoPAFAT; Lyso-PAF acetyltransferase; LPCAT; LPC acyltransferase; Acyltransferase-like; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; AYTL; 1-alkylglycerophosphocholine O-acetyltransferase; 1-acylglycerophosphocholine O-acyltransferase
Gene Name LPCAT1
DTT Type
Successful target
 [1]
UniProt ID
PCAT1_HUMAN ; PCAT2_HUMAN
TTD ID
T30653
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLV
AAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGR
QALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQ
DSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPN
KLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAE
ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEKDLDRYSERAR
MKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDT
IQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFA
EMYPAFAEEYLYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD
Function
Possesses both acyltransferase and acetyltransferase activities. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC), a major component of cell membranes and a PAF precursor.
KEGG Pathway
Glycerophospholipid metabolism (hsa00564 )
Ether lipid metabolism (hsa00565 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Acyl chain remodelling of PG (R-HSA-1482925 )
Synthesis of PA (R-HSA-1483166 )
Synthesis of PC (R-HSA-1483191 )
Neutrophil degranulation (R-HSA-6798695 )
Acyl chain remodelling of PC (R-HSA-1482788 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
B-Lactams DMR8YD6 Bacterial infection 1A00-1C4Z Approved [2]
Quercetin DM3NC4M Obesity 5B81 Approved [1]
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References

1 Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. J Lipid Res. 2003 Feb;44(2):380-7.
2 Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm Res. 1996 Nov;45(11):546-9.