Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTPXAWS)

DTT Name	Heat shock protein 40 (HSP40)
Synonyms	Heat shock 40 kDa protein 1; HSP40; HDJ-1; DnaJ protein homolog 1; DnaJ homolog subfamily B member 1; DNAJB1
Gene Name	DNAJB1
DTT Type	Literature-reported target	[1]
BioChemical Class	Heat shock protein
UniProt ID	DNJB1_HUMAN
TTD ID	T96704
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRK REIFDRYGEEGLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRN GEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCT KKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLK DKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGE GLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI
Function	Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.
KEGG Pathway	Protein processing in endoplasmic reticulum (hsa04141 ) Influenza A (hsa05164 )
Reactome Pathway	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (R-HSA-3371497 ) Attenuation phase (R-HSA-3371568 ) HSF1-dependent transactivation (R-HSA-3371571 ) MAPK6/MAPK4 signaling (R-HSA-5687128 ) Regulation of HSF1-mediated heat shock response (R-HSA-3371453 )

References

1	Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular a... Hum Mol Genet. 2002 Mar 1;11(5):515-23.