Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQ6VF4)

• DTT Name: Ferrochelatase (FECH)
• Synonyms: Protoheme ferro-lyase; Heme synthetase; FECH
• Gene Name: FECH
• DTT Type: Successful target; [1]
• BioChemical Class: Ferrochelatase
• UniProt ID: HEMH_HUMAN
• TTD ID: T42822
• EC Number: EC 4.99.1.1
• Sequence:
  MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
  QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
  EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
  GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
  ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
  WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
  GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
  QQL
• Function: Catalyzes the ferrous insertion into protoporphyrin IX.
• KEGG Pathway:
  Porphyrin and chlorophyll metabolism (hsa00860)
  Metabolic pathways (hsa01100)
• Reactome Pathway: Heme biosynthesis (R-HSA-189451)
• BioCyc Pathway: MetaCyc:HS00891-MON

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[2]
Methyl aminolevulinate	DMIUX3D	Acne vulgaris	ED80	Approved	[1]

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lead acetate	DML0GZ2	Discovery agent	N.A.	Investigative	[3]
N-Methylmesoporphyrin	DM4FMZP	Discovery agent	N.A.	Investigative	[2]
N-Methylmesoporphyrin Containing Copper	DMKZL5H	Discovery agent	N.A.	Investigative	[2]

References

• [1] Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin Cancer Res. 2009 May 15;15(10):3333-43.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] Ferrochelatase, a novel target for photodynamic therapy of cancer. Oncol Rep. 1999 Nov-Dec;6(6):1439-42.