| DTT Name |
RAC serine/threonine-protein kinase (AKT)
|
| Gene Name |
AKT
|
| DTT Type |
Clinical trial target
|
[1] |
| UniProt ID |
AKT1_HUMAN
; AKT2_HUMAN
; AKT3_HUMAN
|
| TTD ID |
|
| 3D Structure |
|
| KEGG Pathway |
- EGFR tyrosine kinase inhibitor resistance (hsa01521 )
- Endocrine resistance (hsa01522 )
- Platinum drug resistance (hsa01524 )
- MAPK signaling pathway (hsa04010 )
- ErbB signaling pathway (hsa04012 )
- Ras signaling pathway (hsa04014 )
- Rap1 signaling pathway (hsa04015 )
- cGMP-PKG signaling pathway (hsa04022 )
- cAMP signaling pathway (hsa04024 )
- Chemokine signaling pathway (hsa04062 )
- HIF-1 signaling pathway (hsa04066 )
- FoxO signaling pathway (hsa04068 )
- Sphingolipid signaling pathway (hsa04071 )
- Phospholipase D signaling pathway (hsa04072 )
- Autophagy - animal (hsa04140 )
- mTOR signaling pathway (hsa04150 )
- PI3K-Akt signaling pathway (hsa04151 )
- AMPK signaling pathway (hsa04152 )
- Apoptosis (hsa04210 )
- Longevity regulating pathway (hsa04211 )
- Longevity regulating pathway - multiple species (hsa04213 )
- Cellular senescence (hsa04218 )
- Adrenergic signaling in cardiomyocytes (hsa04261 )
- VEGF signaling pathway (hsa04370 )
- Apelin signaling pathway (hsa04371 )
- Osteoclast differentiation (hsa04380 )
- Focal adhesion (hsa04510 )
- Signaling pathways regulating pluripotency of stem cells (hsa04550 )
- Platelet activation (hsa04611 )
- Neutrophil extracellular trap formation (hsa04613 )
- Toll-like receptor signaling pathway (hsa04620 )
- C-type lectin receptor signaling pathway (hsa04625 )
- JAK-STAT signaling pathway (hsa04630 )
- T cell receptor signaling pathway (hsa04660 )
- B cell receptor signaling pathway (hsa04662 )
- Fc epsilon RI signaling pathway (hsa04664 )
- Fc gamma R-mediated phagocytosis (hsa04666 )
- TNF signaling pathway (hsa04668 )
- Neurotrophin signaling pathway (hsa04722 )
- Cholinergic synapse (hsa04725 )
- Dopaminergic synapse (hsa04728 )
- Insulin signaling pathway (hsa04910 )
- Progesterone-mediated oocyte maturation (hsa04914 )
- Estrogen signaling pathway (hsa04915 )
- Prolactin signaling pathway (hsa04917 )
- Thyroid hormone signaling pathway (hsa04919 )
- Adipocytokine signaling pathway (hsa04920 )
- Glucagon signaling pathway (hsa04922 )
- Regulation of lipolysis in adipocytes (hsa04923 )
- Relaxin signaling pathway (hsa04926 )
- GnRH secretion (hsa04929 )
- Insulin resistance (hsa04931 )
- Non-alcoholic fatty liver disease (hsa04932 )
- AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
- Growth hormone synthesis, secretion and action (hsa04935 )
- Alcoholic liver disease (hsa04936 )
- Carbohydrate digestion and absorption (hsa04973 )
- Alzheimer disease (hsa05010 )
- Spinocerebellar ataxia (hsa05017 )
- Shigellosis (hsa05131 )
- Salmonella infection (hsa05132 )
- Yersinia infection (hsa05135 )
- Chagas disease (hsa05142 )
- Toxoplasmosis (hsa05145 )
- Tuberculosis (hsa05152 )
- Hepatitis C (hsa05160 )
- Hepatitis B (hsa05161 )
- Measles (hsa05162 )
- Human cytomegalovirus infection (hsa05163 )
- Influenza A (hsa05164 )
- Human papillomavirus infection (hsa05165 )
- Human T-cell leukemia virus 1 infection (hsa05166 )
- Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
- Herpes simplex virus 1 infection (hsa05168 )
- Epstein-Barr virus infection (hsa05169 )
- Human immunodeficiency virus 1 infection (hsa05170 )
- Pathways in cancer (hsa05200 )
- Proteoglycans in cancer (hsa05205 )
- Chemical carcinogenesis - receptor activation (hsa05207 )
- Chemical carcinogenesis - reactive oxygen species (hsa05208 )
- Colorectal cancer (hsa05210 )
- Renal cell carcinoma (hsa05211 )
- Pancreatic cancer (hsa05212 )
- Endometrial cancer (hsa05213 )
- Glioma (hsa05214 )
- Prostate cancer (hsa05215 )
- Melanoma (hsa05218 )
- Chronic myeloid leukemia (hsa05220 )
- Acute myeloid leukemia (hsa05221 )
- Small cell lung cancer (hsa05222 )
- Non-small cell lung cancer (hsa05223 )
- Breast cancer (hsa05224 )
- Hepatocellular carcinoma (hsa05225 )
- Gastric cancer (hsa05226 )
- Central carbon metabolism in cancer (hsa05230 )
- Choline metabolism in cancer (hsa05231 )
- PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
- Diabetic cardiomyopathy (hsa05415 )
- Lipid and atherosclerosis (hsa05417 )
- Fluid shear stress and atherosclerosis (hsa05418 )
|
| Reactome Pathway |
- PIP3 activates AKT signaling (R-HSA-1257604 )
- Downregulation of ERBB2 (R-HSA-1358803 )
- Translocation of SLC2A4 (GLUT4) to the plasma membrane (R-HSA-1445148 )
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (R-HSA-1474151 )
- MTOR signalling (R-HSA-165159 )
- AKT phosphorylates targets in the cytosol (R-HSA-198323 )
- AKT phosphorylates targets in the nucleus (R-HSA-198693 )
- Negative regulation of the PI3K/AKT network (R-HSA-199418 )
- eNOS activation (R-HSA-203615 )
- AKT-mediated inactivation of FOXO1A (R-HSA-211163 )
- Integrin signaling (R-HSA-354192 )
- Deactivation of the beta-catenin transactivating complex (R-HSA-3769402 )
- CD28 dependent PI3K/Akt signaling (R-HSA-389357 )
- CTLA4 inhibitory signaling (R-HSA-389513 )
- G beta (R-HSA-392451 )
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (R-HSA-450385 )
- KSRP (KHSRP) binds and destabilizes mRNA (R-HSA-450604 )
- VEGFR2 mediated vascular permeability (R-HSA-5218920 )
- TP53 Regulates Metabolic Genes (R-HSA-5628897 )
- Constitutive Signaling by AKT1 E17K in Cancer (R-HSA-5674400 )
- Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807 )
- Regulation of TP53 Degradation (R-HSA-6804757 )
- Regulation of TP53 Activity through Acetylation (R-HSA-6804758 )
- Regulation of TP53 Activity through Association with Co-factors (R-HSA-6804759 )
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (R-HSA-6811558 )
- Cyclin E associated events during G1/S transition (R-HSA-69202 )
- Cyclin A (R-HSA-69656 )
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (R-HSA-8849469 )
- RAB GEFs exchange GTP for GDP on RABs (R-HSA-8876198 )
- RUNX2 regulates genes involved in cell migration (R-HSA-8941332 )
- Regulation of PTEN stability and activity (R-HSA-8948751 )
- Extra-nuclear estrogen signaling (R-HSA-9009391 )
- Negative regulation of NOTCH4 signaling (R-HSA-9604323 )
- FLT3 Signaling (R-HSA-9607240 )
- Regulation of localization of FOXO transcription factors (R-HSA-9614399 )
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling (R-HSA-9634638 )
- KEAP1-NFE2L2 pathway (R-HSA-9755511 )
- SARS-CoV-2 targets host intracellular signalling and regulatory pathways (R-HSA-9755779 )
- Activation of BAD and translocation to mitochondria (R-HSA-111447 )
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