Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQA8DT)

DTT Name	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (PIGL)
Synonyms	Phosphatidylinositol-glycan biosynthesis, class L protein; PIGL; PIG-L; GlcNAc-PI de-N-acetylase
Gene Name	PIGL
DTT Type	Literature-reported target	[1]
BioChemical Class	Carbon-nitrogen hydrolase
UniProt ID	PIGL_HUMAN
TTD ID	T27747
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.5.1.89
Sequence	MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPT VLGLARLRHWVYLLCFSAGNYYNQGETRKKELLQSCDVLGIPLSSVMIIDNRDFPDDPGM QWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVL TLQSVNVLRKYISLLDLPLSLLHTQDVLFVLNSKEVAQAKKAMSCHRSQLLWFRRLYIIF SRYMRINSLSFL
Function	Involved in thesecond step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol.
KEGG Pathway	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis (hsa00563 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Synthesis of glycosylphosphatidylinositol (GPI) (R-HSA-162710 )

References

1	Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol bi... J Biol Chem. 2002 Dec 20;277(51):50176-82.