Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQAFX5)

DTT Name	Myelin-oligodendrocyte glycoprotein (MOG)
Synonyms	Myelinoligodendrocyte glycoprotein; MOG
Gene Name	MOG
DTT Type	Literature-reported target	[1]
BioChemical Class	Immunoglobulin
UniProt ID	MOG_HUMAN
TTD ID	T00295
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MASLSRPSLPSCLCSFLLLLLLQVSSSYAGQFRVIGPRHPIRALVGDEVELPCRISPGKN ATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRFS DEGGFTCFFRDHSYQEEAAMELKVEDPFYWVSPGVLVLLAVLPVLLLQITVGLIFLCLQY RLRGKLRAEIENLHRTFDPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLAGQFL EELRNPF
Function	Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. {ECO:0000250}.

References

1	HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclero... Int Immunol. 2003 Apr;15(4):535-46.