Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQD0YT)

DTT Name	Alpha-endosulfine (ENSA)
Synonyms	ENSA; ARPP19e
Gene Name	ENSA
DTT Type	Literature-reported target	[1]
BioChemical Class	Endosulfine family
UniProt ID	ENSA_HUMAN
TTD ID	T58460
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQK GQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQV E
Function	Endogenous ligand for sulfonylurea receptor. By inhibitingsulfonylurea from binding to the receptor, it reduces k(atp) channel currents and thereby stimulates insulin secretion.
Reactome Pathway	MASTL Facilitates Mitotic Progression (R-HSA-2465910 )

References

1	Brain alpha-endosulfine is manifold decreased in brains from patients with Alzheimer's disease: a tentative marker and drug target Neurosci Lett. 2001 Sep 14;310(2-3):77-80.