Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQOD3G)

DTT Name	Folate receptor (FOLR)
Synonyms	FR; FOLR
Gene Name	NO-GeName
DTT Type	Successful target	[1]
Related Disease	Folate deficiency anaemia [ICD-11: 3A02] Nutritional deficiency [ICD-11: 5B50-5B71]
BioChemical Class	Folate receptor
UniProt ID	NOUNIPROTAC
TTD ID	T87467
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform short does not bind folate.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[2]
Tetrahydrofolic acid	DMH15UV	Malnutrition	5B50-5B71	Approved	[1]
------------------------------------------------------------------------------------

References

1	Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 Apr 15;102(2):115-20.
2	Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. 2006 Dec;374(1-2):25-32.